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(Source: Neuropathology and Applied Neurobiology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising....
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Cell migration involves different mechanisms in different cell types and tissue environments. Changes in migratory behaviour have been observed experimentally and associated with phenotypic switching in various situations, such as the migration–proliferation dichotomy of glioma cells, the epithelial–mesenchymal transition or the mesenchymal–amoeboid transition of fibrosarcoma cells in the extracellular matrix ...
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This study investigated the pattern of protein expression in brain tumor and normal brain tissue, following treatment with vandetanib in a rat glioma model. BT4C-cells were stereotactically implanted into the brain of BD IX rats. The rats were divided into three different experiments. The treatment schedule for experiments one and ...
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World Health Organization grade II gliomas (GIIG) are diffuse, slow-growing, primary neuroectodermal tumors that occur in the central nervous system. They are generally seen in young individuals and are slightly more common in Whites and males. Most patients present with seizures but neurologic deficits are rare. Magnetic resonance imaging best ...
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Abstract
Fluorodeoxyglucose positron emission tomography (FDG-PET) plays an increasingly important role in radiotherapy, beyond staging
and selection of patients. Especially for non-small cell lung cancer, FDG-PET has, in the majority of the patients, led to
the safe decrease of radiotherapy volumes, enabling radiation dose escalation and, experimentally, redistribution of radiation
...
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This study investigated the safety of administering TMZ to children and adolescents with brain tumors over an extended period.
Extended schedules have been proven to overcome chemoresistance without any major toxicity. The toxicity of TMZ, administered
at 70 mg/m2/day orally for 21 consecutive days every 28 days, was assessed in children with ...
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Abstract Over the last decade, understanding of glioma on a molecular level has greatly expanded. However, optimal incorporation of
molecular markers into clinical care is controversial. We briefly review the potential utility of molecular stratification
in refining histologic diagnosis, prognosis, and treatment decisions, focussing on 1p/19q co-deletion, MGMT promoter methylation, EGFR ...
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Abstract The purpose of this study is to determine whether the expressions of MMP-7 and MMP-14 are associated with the ERK 1/2 signaling
pathway in human brain gliomas of different pathological grades. Immunohistochemistry and western blot methods were used to
determine the expressions of MMP-7, MMP-14 and the phosphorylation status of ...
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Abstract Gliomas are the most common primary intracranial tumors. Understanding the molecular basis of gliomasâ progression is required
to develop more effective therapies. The Wnt/β-catenin signaling cascade is an important signal transduction pathway in human
cancers. Although, overactivation of this pathway is a hallmark of several forms of cancer, little is ...
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Abstract The discovery of a genetic signature of chemosensitivity and prognosis in oligodendroglial tumours prompted a new optimism
in glioma management. After more than a decade since the initial reports, where do we stand in the current management of oligodendroglial
tumours? This review focuses on the latest molecular genetics, imaging characteristics, ...
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Conclusion:
To our knowledge, these data indicate for the first time that miR-221/222 directly regulate apoptosis by targeting PUMA in glioblastoma and that miR-221/222 could be potential therapeutic targets for glioblastoma intervention. (Source: Molecular Cancer)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising....
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In conclusion, alphaBc is overexpressed by highly migratory glioma cells where it plays a functional role in apoptosis resistance.
PMID: 20813964 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)...
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Malignant gliomas are treated with a combination of surgery, radiation, and temozolomide (TMZ), but these therapies ultimately fail due to tumor recurrence. In glioma cultures, TMZ treatment significantly decreases neurosphere formation; however, a small percentage of cells survive and repopulate the culture. A promising target for glioma therapy is the ...
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Conclusions:
Human GBMs overexpress MRP3 at both mRNA and protein levels, and elevated MRP3 mRNA levels in GBM biopsy samples correlated with a higher risk of death. These data suggest that the tumor-associated antigen MRP3 has potential use for prognosis and as a target for malignant glioma immunotherapy. (Source: BMC ...
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(Source: Veterinary Radiology and Ultrasound)...
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Summary.â (Source: Journal of Thrombosis and Haemostasis)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising....
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Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein... (Source: Proceedings of the National Academy of Sciences)...
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CD133 is widely used as a marker for the isolation and characterization of normal and cancer stem cells. The dynamic alternation of CD133 glycosylation contributes to the isolation of normal and cancer stem cells, and is supposed to be associated with cell differentiation. Although CD133 has been identified as a ...
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Authors: N E Savaskan, S Seufert, J Hauke, C Tränkle, I Y Eyüpoglu
& E Hahnen (Source: Oncogene)...
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(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising....
