My Patient Information Canvass For The Influenza Vaccine For Informed Consent.

My Patient Info Sheet for the Flu Vaccine for Informed Consent

For the Pro side delight see the
It is of import to review both sets of information to brand an informed decision.
1. Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al ... (n.d.). Retrieved from

Collaboration report included xl clinical trial studies of to a greater extent than than 70,000 people a perfectly matched year, it showed upward to 80% produce goodness but since that oftentimes doesn’t happen, it listed 50% effectiveness to every bit depression every bit 30% effectiveness alongside the flu vaccine. So but every bit many people theoretically benefited every bit didn’t on an average year.  It showed little days lost from run too NO evidence was constitute to decrease hospitalization or complication rates. Another analysis position it this way.  When the vaccine matched the flu strain, 4 pct who weren’t vaccinated got the flu. One pct of vaccinated people got it. That’s a divergence of 3 percent. When the vaccine didn’t gibe the strain, 2 pct of unvaccinated people got the flu, too 1 pct didn’t, for a divergence of 1 percent.

2.  Kelley NS, Manske JM, Ballering KS, Leighton TR, Moore KA.  The Compelling Need for Game-Changing Influenza Vaccines, An analysis of the flu vaccine enterprise too recommendations for the future.  Center for Infectious Disease Research & Policy, Oct 2012.

It removed to a greater extent than of the “flawed” studies too constitute that inwards a perfectly matched year, it was 59% effective inwards having the vaccine inwards the ages of 18-64.  It showed no produce goodness inwards the elderly (over 65) or nether eighteen has been seen inwards other studies.  Their newspaper suggests that the flu vaccine is non ideal but due to lack of fiscal incentive, to a greater extent than beneficial vaccines are non probable to last found.

3. Cowling, Fang, Kwok-Hung. Increased Non-Influenza Respiratory Virus Infections Associated alongside receipt of the Inactivated Influenza Vaccine. Clinical Infectious Diseases, Vol. 54, Issue 12, June 2012 pages 1778-1783, also inwards Clin Infect Dis 2012 June 15; 54(12): 1778-83

TIV (trivalent inactivated flu vaccine) recipients had higher adventure of confirmed non-influenza respiratory virus infection (RR, 3.46;95% Cl, 1.19-10.1) The bulk of the non-influenzas respiratory virus detection were rhinoviruses too coxsackie/echoviruses, too the increased adventure amidst TIV recipients was also statistically important for these viruses.

4.  Minn, Michael, McCullers, J., Klugman, K.  Live Attenuated Influenza Vaccine Enhance Colonization of Steptococcus Pneumonia too Staphylococcus Aureus inwards Mice, mBio 5(1) doi:10.1128/mBio.01040-13

The strong too oftentimes lethal effects of an antecedent flu virus infection on secondary bacterial affliction accept been reported. Viral replication induced epithelial too mucosal degradation, too the ensuing innate immune answer yield diminished capacity to avert secondary bacterial infections. Recent clinical too experimental information propose that flu virus infection may exert its influence outset inwards the URT past times enhancing susceptibility to bacterial colonization.

5.  Goldman GS Comparison of VAERS fetal-loss reports during 3 consecutive flu seasons: Was in that location a synergistic fetal toxicity associated alongside the two- vaccine 2009-2019 season? Hum. Exp Toxicol. 2013 May;32(5): 464-75

There were 77.8 fetal loss reports per 1 1 grand m meaning women vaccinated during the 2009/2010 2 dose flu flavor vs 6.8 fetal loss reports during the previous 1-dose flu season.  An 11.4-fold increase.  The 2 multidose vials incorporate 25 mcg of mercury per dose those years.

6. Jefferson T, Rivetti A, et al.  Vaccines for preventing flu inwards good for y'all children. Cochrane Database Syst. Rev 2012 Aug 15; Issue 8: CD 004879

75 worldwide studies, Inc 17 randomized trials, inwards children older than 2, the inactivated flu vaccine is nigh 36% effective.  Under 2 it was equal to placebo, no evidence to present reduced mortality, infirmary admissions, serious complications or community transmission of influenza.

7. Jefferson T, Smith S, et al. Assessment of the efficacy too effectiveness of flu vaccines inwards good for y'all children: systematic review.  Lancet 2005 February 26; 365 (9461) : 773-80

No evidence of reduced mortality, admissions, complications, or decreased community transmission of influenza.

8.   Joshi, AY, Iyer VN, et al. Effectiveness of trivalent inactivated flu vaccine inwards influenza-related hospitalization inwards children: a case-control study.  Allergy Ashthma Proc 2012 Mar-Apr;33(2): e23-7

Study of kids half-dozen months to eighteen years from 1999-2007.  Children who were vaccinated against flu were 3 times to a greater extent than probable to last hospitalized for flu related complications than children who did non have an flu vaccine (OR=3.67).  Asthmatic children who received the flu vaccine were also to a greater extent than probable to last hospitalized than those who did non have it.  The severity of asthma did non comport on the outcome.

9. Seasonal Influenza too Vaccine Herd Effect

Study 1968-2001-Observational study showed no decreased mortality charge per unit of measurement alongside increasing vaccination from 15% to 65%

10.Thomas RE, Jefferson T, Lasserson TJ Influenza vaccination for wellness attention workers who attention for people aged lx or older living inwards long-term attention institutions.  Cochrane Database Syst Rev 2013 ; Issue 7: CD 005187

No evidence to back upward that vaccinating healthcare workers inwards long-term attention facilities showed effect on laboratory proven flu or complications (pneumonia, hospitalization, or decease due to pneumonia) inwards those residence over historic flow 60.

11. Doshi, P. (2013). Influenza: Marketing vaccine past times marketing disease. Bmj, 346(May16 1). doi:10.1136/bmj.f3037

Too much to listing to explicate but worth the read.

12.  Doshi, P. (2005). Are USA flu decease figures to a greater extent than PR than science? Bmj, 331(7529), 1412. doi:10.1136/bmj.331.7529.1412 
       (Basically, discusses this information on this page)

13. Carrat, F., Lavenu, A. et al, Repeated flu vaccination of good for y'all children too adults borrow now, pay later? Epidemiol. Infect. (2006) 134, 63-70 

Shows that repeated flu vaccination at a younger historic flow substantially increases the adventure of flu inwards older age

14.Phone conversation with (protected advert now), MD, MPH, CAPT, USPHS Medical Officer Epidemiology too Prevention Branch Influenza Division, NCIRD Centers for Disease Control too Prevention

Agreed alongside all information hither too says this is the best nosotros tin sack do.  Due to lack of evidence, they produce non officially endorse flu vaccine mandates.  Also she admits that nosotros volition never accept skillful studies due to changing viral strains too vaccines that may non match.

15. Skowronski DM, De Serres G, et al.  Association betwixt 2008-2009 seasonal flu vaccine too pandemic H1N1 illness during Spring-Summer 2009:four observational studies from Canada PLoS Med 2010 Apr 6; 7(4) e1000258

Recipients of the flu vaccine had significantly increment flu compared to those who didn’t.  Recipients had increased demand for requiring medical attending due to the H1N1 virus.

16.  Link: Carl Grays article on Time Management seemed to become ... (1998). Bmj, 316(7149). doi:10.1136/bmj.316.7149.3a

In adjusted models, nosotros observed 6.3 (95% CI 1.9–21.5) times to a greater extent than aerosol shedding amidst cases alongside vaccination inwards the electrical current too previous flavor compared alongside having no vaccination inwards those 2 seasons.”

“those who were vaccinated 3 years inwards a row genuinely had an increased adventure of contracting flu compared alongside unvaccinated participants....”

Prior twelvemonth vaccination cutting the electrical current twelvemonth efficacy of the flu vaccine.

Children who instruct the flu vaccine accept 3 times the charge per unit of measurement of hospitalization for flu.

20.Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion too Enhance Influenza Virus Respiratory Disease, Sci Transl Med 28 August 2013: Vol. 5, Issue 200, p. 200ra114 Sci. Transl. Med.

"A novel study inwards the U.S. has shown that pigs vaccinated against 1 strain of flu were worse off if afterwards infected past times a related strain of the virus."

21.Effectiveness of trivalent inactivated flu vaccine inwards influenza-related hospitalization inwards children: a case-control study. Joshi AY1, Iyer VN, Hartz MF, Patel AM, Li JT
TIV (The inactivated flu vaccine) did non render whatever protection against hospitalization inwards pediatric subjects, particularly children alongside asthma. On the contrary, nosotros constitute a threefold increased adventure of hospitalization inwards subjects who did instruct the TIV vaccine.

22.Influenza vaccines seem to last modifying flu into a unsafe dengue similar disease.

23.Death rates due to actual positive flu tests average nether 1000 per twelvemonth inwards over 300,000,000 patients according to the CDC National Vital Statistics Report.   The number that y'all listen inwards the media of 30K to 50K deaths are due to flu AND pneumonia (all crusade pneumonia including from HIV, COPD, elderly, cancer etc).   The number is inflated to increment flu vaccination. Pediatric flu deaths are reportable too arrive at from 60-120 annually.  Adult flu deaths are non reportable but obtained via decease certificates too then that gives liberty for "estimation" to become from a 1000 to the 10's of thousands alongside no existent proof.  It is foreign that if in that location are 30-50K deaths from flu too pneumonia that 80% would last from flu when it alone happens a few months out of the year.  

24. Adverse reactions- flawed due to reporter bias.  Our preparation is to tell that whatever important flu similar illness is probable coincidence or would accept been worse without the vaccine.  We are non trained to recognize serum sickness too nosotros are also besides busy to report.
Miller’s Review of Critical Vaccine Studies used every bit a resource

25.Nanri, A., Nakamoto, K., Sakamoto, N., Imai, T., Akter, S., Nonaka, D., & Mizoue, T. (2017). Association of serum 25-hydroxyvitamin D alongside flu inwards case-control study nested inwards a cohort of Japanese employees. Clinical Nutrition, 36(5), 1288-1293. doi:10.1016/j.clnu.2016.08.016

Lower flu adventure associated alongside vitamin D sufficiency amidst unvaccinated participants warrants farther investigation. 


26. Roos R. Study: Prior-year vaccination cutting flu vaccine effects inwards 2014-15. CIDRP News. In: Center for Infectious Disease Research too Policy website. Available at Accessed 08Nov16. 
27.  Smith DJ, Forrest S, Ackley DH, Perelson AS. Variable efficacy of repeated annual flu vaccination. Proc Natl Acad Sci U southward Influenza A virus subtype H5N1 1999; 96:14001–6. Available at
28. Skowronski, D. M., & Serres, G. D. (2018). Role of Egg-adaptation Mutations inwards Low Influenza A(H3N2) Vaccine Effectiveness During the 2012–2013 Season. Clinical Infectious Diseases. doi:10.1093/cid/ciy350 
Using a illustration command study pattern too information from Canada's Sentinel Practitioner Surveillance Network (SPSN) for the 2014-2015 flu season, Dr. Skowronski’s grouping reported that study participants who received the 2014–2015 vaccine without vaccination the twelvemonth earlier had important protection against flu A(H3N2) but those who had received the identical 2013-2014 vaccine the previous twelvemonth had no increased protection too those who were vaccinated 3 years inwards a row genuinely had an increased adventure of contracting flu compared alongside unvaccinated participants. 

29. Systemic autoimmunity appears to last the inevitable number of over-stimulating the host’s immune organisation past times repeated immunization.
30. The Autoimmune/Inflammatory Syndrome induced past times adjuvants (ASIA)     

31.Subgroup analysis demonstrates that immunosuppressive therapies too the nonadjuvanted atomic number 82 to less immunogenicity inwards humoral answer inwards flu-vaccinated SLE patients.

33. “...This study shows that children aged 4 years too nether who had received TIV from 1 vaccine manufacturer (CSL Biotherapies) had a 200-fold higher charge per unit of measurement of febrile convulsions than that of the alone reliable published estimate...”


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