AF is an abnormal pump beat characterized past times rapid as well as irregular beating of the atria (the ii upper chambers of the heart). Observational studies propose that fifty-fifty moderate regular alcohol consumption may growth the run a peril of AF. H5N1 meta-analysis of 7 studies involving nearly 860,000 patients as well as about 12,500 individuals with AF demonstrated an viii per centum growth inwards incident AF for each additional daily measure drink. Despite the association betwixt regular alcohol intake as well as AF, however, detailed human electrophysiological studies describing the nature of alcohol-related atrial remodeling get got been lacking.
The role of this study was to arrive at upwardly one's hear the affect of dissimilar degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping. In this multi-center cross-sectional study inwards Australia, investigators performed detailed invasive testing on the atria of 75 patients with AF, 25 inwards each of 3 categories: lifelong non-drinkers, mild drinkers, as well as moderate drinkers. Patients self-reported their average alcohol consumption inwards measure drinks per calendar week (one measure drinking glass is about 12 grams of alcohol) over the preceding 12 months. Patients consuming ii to 7 drinks per calendar week were considered mild drinkers, land those consuming viii to 21 drinks per calendar week (average xiv drinks per week) were defined equally moderate drinkers.
The investigators found that individuals who consumed moderate amounts of alcohol (average xiv drinks per week) had to a greater extent than electrical show of scarring as well as impairments inwards electrical signaling than non-drinkers as well as lite drinkers.
"This study underscores the importance of excessive alcohol consumption equally an of import run a peril ingredient inwards AF," said atomic number 82 investigator Professor Peter Kistler, MBBS, PhD, FHRS, from the Heart Centre, Alfred Hospital, Melbourne, Australia. "Regular moderate alcohol consumption, only non mild consumption, is an of import modifiable run a peril ingredient for AF associated with lower atrial voltage as well as conduction slowing. These electrical as well as structural changes may explicate the propensity to AF inwards regular drinkers. It is an of import reminder for clinicians who are caring for patients with AF to enquire almost alcohol consumption as well as supply appropriate counselling inwards those who over-indulge."